Imaging the liver and biliary tract
A variety of modalities is available to image the liver and biliary tract, many offering complementary information; a combination of techniques is often required to make the diagnosis or determine…
Drug-induced liver injury
Lack of substantial advances in pre-clinical testing for hepatotoxicity has meant that drug-induced liver injury (DILI) remains an important issue during both the drug development and post-marketing phases. A number…
Histological assessment
Histopathological assessments play an important role in the diagnosis and management of patients with liver disease. For some conditions, liver biopsy is still routinely used to establish the cause of…
Hepatobiliary tumours
Hepatocellular carcinoma (HCC) and cholangiocarcinoma are the two major types of primary liver tumour. Both are increasing in incidence in the UK, in the case of HCC because of the…
Tropical liver disease
The liver is frequently involved in infections that are prevalent in different regions of the tropics, and chronic liver disease, sometimes with multiple aetiological explanations, is an important cause of…
Hepatitis B and D
Chronic hepatitis B (CHB) remains a major global healthcare challenge with changing epidemiology and increasing morbidity and mortality from the complications of liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B…
Alcohol and the liver
Hospital admissions because of alcohol-related liver disease (ArLD) are increasing. The amount of alcohol consumed and pattern of drinking are linked to increased risk of ArLD. However, other factors such…
Investigation of jaundice
Jaundice, also known as icterus, is a yellowing of the skin, whites of the eyes, and body fluids due to an increase in the amount of bilirubin in the blood.…
Prescribing in liver disease
Patients with liver disease often require drug therapy. Because the liver is the main site of drug detoxification and elimination, each patient's need for therapy must be carefully assessed; the…
