RAPID PLASMA REAGIN (RPR) CARD TEST / CARBON ANTIGEN FOR SYPHILIS TESTING

Syphilis is a sexually transmitted (venereal) disease caused by the spirochete Treponema pallidum. After infection the host forms Treponemal antibodies to Treponema pal/idum, in addition, the host also forms Non Treponemal antilipoidal antibodies in response to the lipoidal material released from the damaged host cell. These antibodies are traditionally referred to as ‘Reagins.’

The Rapid Plasma Reagin (RPR) / Carbon Antigen test is a macroscopic nonTreponemal flocculation test for the detection and quantitation of antilipoidal antibodies. Non-Treponemal tests like CARBOGEN® are of great value when used for screening and follow up of therapy.

REAGENTS
1. CARBOGEN® reagent: A particulate carbon suspension coated with lipid complexes.
2. Positive control, reactive with the CARBOGEN® reagent.
3. Negative control, non reactive with theCARBOGEN® reagent.
CARBOGEN® detects antilipoidal antibodies in serum or plasma. As against the conventional V.D.R.L. reagents, test samples do not require heat inactivation.
Each batch of reagent undergoes rigorous quality control at various stages of manufacture for its specificity, sensitivity and performance.